For people affected with lupus aspirin can be effective in treating malaise and other headaches caused by lupus. Indeed, aspirin has pain-reducing, anti-inflammatory, and anticoagulant (blood-thinning) properties that can help control some of the symptoms of lupus.

Low doses of aspirin taken once a day may help reduce the risk of blood clots and miscarriage in lupus patients who have antiphospholipid antibodies. It is possible that your doctor may recommend that you take one low dose of aspirin daily if your type of lupus is appropriate for the intake of aspirin.  This recommendation is common because low doses of aspirin have been shown to lower the potential for clot-forming blood cells that stick together in narrow blood vessels. Low doses of aspirins are often grouped with antiplatelet medications because they help treat certain lupus symptoms such as: fevers, headaches, muscle aches, malaise, arthritis, & serositis.


How Can Aspirin’s Mechanism of Action Help with Lupus?


For people affect with SLE aspirin’s ability to suppress the production of prostaglandins and thromboxanes can be effective in the treatment of the disease. This successful action is due to aspirin’s irreversible inactivation of the cyclooxygenase enzyme required for prostaglandin and thromboxane synthesis. Moreover, aspirin acts as an acetylating agent that makes it different from other NSAIDs, which are reversible inhibitors, thus a valuable option for lupus treatments.

Low-dose aspirin use will irreversibly block the formation of thromboxane A2 in platelets which will produce an inhibitory effect on platelet aggregation which makes aspirin useful in, for instance, reducing the incidence of heart attacks caused by lupus. Several doctors would recommend a dose of 40 mg of aspirin a day. Such dosage might be able to inhibit a large proportion of maximum thromboxane; however, higher doses of aspirin are required to attain further inhibition.

Aspirin has been shown to have at least three additional modes of action. One of them is the uncoupling of oxidative phosphorylation in cartilaginous (and hepatic) mitochondria. The other mode of actions is the buffering and transportation of protons. When high doses of aspirin are given, these doses may actually cause fever due to the heat released from the electron transport chain.  In the final mode of action, aspirin induces the formation of NO-radicals in the body, which has been shown in mice to have an independent mechanism of reducing inflammation.